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Reduction in the activity of genes such as the one that regulates the enzyme methyl-enetetrahydrofolate reductase (MTHFR) increases mean homocysteine levels

Similarly to garlic, pumpkin is also known for its multiple beneficial effects, such as anti-diabetic, anti-hypertensive, anti-tumor, anti-bacterial, anti-viral, anti-fungal, hypocholesteremic, anti-ulcer, anti-inflammatory, and analgesic effects (Jafarian et al., 2012

It affects metabolism, oxidation, and aging via sirtuin pathway activation

The reduction of these disulfide bonds results in oxidation of thioredoxin which then is reduced by thioredoxin reductase